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Active D-2-Hydroxyglutaratate Dehydrogenase (D2HGDH), Recombinant
D-2-hydroxyglutarate dehydrogenase, D2HGDH, D2HGD
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | N/A |
|---|---|
| Calculated MW | 39 kDa |
| Other Names | D-2-hydroxyglutarate dehydrogenase, D2HGDH, D2HGD |
|---|---|
| Gene Source | Acidaminococcus fermentans |
| Source | E. coli |
| Assay&Purity | SDS-PAGE;≥99% |
| Recombinant | Yes |
| Sequence | Full-length his-tagged D2HGDH |
| Target/Specificity | D2HGDH |
| Application Notes | Reconstitute in water to a concentration of 0.1-5 mg/ml. The solution can be diluted into other aqueous buffers and stored at –20°C for future use. |
| Format | Dry powder |
| Storage | -20°C;Lyophilized powder |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
D-2-hydroxyglutarate (D2HG) level is significantly increased in metabolic diseases and various cancers such as acute myeloid leukemia. Studies suggest that the detection of D2HG serves as a biomarker assay related to IDH (isocitrate dehydrogenase) mutations. D2HGDH is a special NAD-dependent enzyme which reacts with D2HG specifically and converts D2HG to α-ketoglutarate. D2HGDH is a key enzyme to distinguish between two metabolites, D2HG and L-2-hydroxyglutarate (L2HG), during biomarker assays.
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