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IL1RN Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • IF - IL1RN Antibody (C-term) AP6503b
    Confocal immunofluorescent analysis of IL1RN Antibody (C-term)(Cat#AP6503b) with WiDr cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
    detail
  • WB - IL1RN Antibody (C-term) AP6503b
    Anti-IL1RN Antibody (C-term) at 1:4000 dilution + 293 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 20 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
    detail
  • WB - IL1RN Antibody (C-term) AP6503b
    IL1RN Antibody (C-term) (Cat.# AP6503b) western blot analysis in 293,Hela cell line lysates (35ug/lane).This demonstrates the IL1RN antibody detected the IL1RN protein (arrow).
    detail
  • FC - IL1RN Antibody (C-term) AP6503b
    IL1RN Antibody (C-term) (Cat. #AP6503b) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, FC, E
Primary Accession P18510
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 20055 Da
Antigen Region 147-177 aa
Additional Information
Gene ID 3557
Other Names Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, ICIL-1RA, IL1 inhibitor, Anakinra, IL1RN, IL1F3, IL1RA
Target/Specificity This IL1RN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-177 amino acids from the C-terminal region of human IL1RN.
Dilution IF~~1:10~50
WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL1RN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL1RN
Synonyms IL1F3, IL1RA
Function Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
Cellular Location [Isoform 1]: Secreted [Isoform 3]: Cytoplasm.
Tissue Location The intracellular form of IL1RN is predominantly expressed in epithelial cells
Research Areas
Citations (0)
citation

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Background

The protein is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of its gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer.

References

Kumar,S., Biochem. Biophys. Res. Commun. 387 (3), 456-460 (2009) Rechcinski,T., Kardiol Pol 67 (6), 601-610 (2009)

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$ 365.00
$ 140.00
Cat# AP6503b
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