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IL1RN Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • IF - IL1RN Antibody (Center) AP6503a
    Confocal immunofluorescent analysis of IL1RN Antibody (Center)(Cat#AP6503a) with WiDr cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
    detail
  • WB - IL1RN Antibody (Center) AP6503a
    Western blot analysis of IL1RN (arrow) using rabbit polyclonal IL1RN Antibody (Center) (Cat. #AP6503a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the IL1RN gene (Lane 2) (Origene Technologies).
    detail
  • IHC-P - IL1RN Antibody (Center) AP6503a
    IL1RN Antibody (Center) (RB18901) IHC analysis in formalin fixed and paraffin embedded human Colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IL1RN Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
    detail
  • FC - IL1RN Antibody (Center) AP6503a
    IL1RN Antibody (Center) (Cat. #AP6503a) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, IF, IHC-P, WB, E
Primary Accession P18510
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 20055 Da
Antigen Region 100-129 aa
Additional Information
Gene ID 3557
Other Names Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, ICIL-1RA, IL1 inhibitor, Anakinra, IL1RN, IL1F3, IL1RA
Target/Specificity This IL1RN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-129 amino acids from the Central region of human IL1RN.
Dilution IF~~1:10~50
WB~~1:1000
IHC-P~~1:10~50
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL1RN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL1RN
Synonyms IL1F3, IL1RA
Function Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
Cellular Location [Isoform 1]: Secreted [Isoform 3]: Cytoplasm.
Tissue Location The intracellular form of IL1RN is predominantly expressed in epithelial cells
Research Areas
Citations (0)
citation

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Background

The protein is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of its gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer.

References

Kumar,S., Biochem. Biophys. Res. Commun. 387 (3), 456-460 (2009)
Rechcinski,T., Kardiol Pol 67 (6), 601-610 (2009)

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$ 365.00
$ 140.00
Cat# AP6503a
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