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ADH4 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 3
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P08319 |
| Other Accession | NP_000661.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 40222 Da |
| Antigen Region | 319-348 aa |
| Gene ID | 127 |
|---|---|
| Other Names | Alcohol dehydrogenase 4, Alcohol dehydrogenase class II pi chain, ADH4 |
| Target/Specificity | This ADH4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 319-348 amino acids from the C-terminal region of human ADH4. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ADH4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADH4 (HGNC:252) |
|---|---|
| Function | Catalyzes the NAD-dependent oxidation of either all-trans- retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (PubMed:10514444). |
| Cellular Location | Cytoplasm. |
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.
References
Pochareddy, S., et al. Gene 460 (1-2), 1-7 (2010) :
Preuss, U.W., et al. Addict Biol (2010) In press :
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Rainero, I., et al. Headache 50(1):92-98(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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