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>   home   >   pathways   >   Interactive ErbB_HER Pathway

Interactive ErbB_HER Pathway

erbb-pathwayClick on any interested protein or antibody ID in the Erb_HER pathway to list relevant products below.

Her/ErbB receptor tyrosine kinases are activated upon ligand binding and dimerization. They signal through Akt, MAPK, and other pathways to regulate proliferation, differentiation, apoptosis, migration, and motility. Reduced ErbB signaling is linked to neurodegenerative diseases such as multiple sclerosis and Alzheimer's. Cancers associated with mutation or increased expression of Her/ErbBs include lung, breast, stomach, colorectal, head and neck, and pancreatic cancers.

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